Abstract:ObjectiveTo study the risk factors of drug resistance of HIV cases received antiretroviral therapy in Fujian for the disease control. MethodsThe cases received antiretroviral therapy ≥one year with viral load of HIV1 in plasma ≥1 000 copy/ml were collected for detecting drug resistance and analyzed for the influencing factors. ResultsTotally 308 samples with viral load of HIV1 in plasma ≥1 000 copy/ml were collected,in which 76 samples occurred drug resistance(24.7%).The main resistance mutations were M184V,D67N,K103N,G190A and so on.Multivariate logistic regression analysis shown that male,unmarried,NVP+3TC+D4T initial antiretroviral therapy,longer duration of therapy,missing medication were risk factors for HIV drug resistance. ConclusionThe rate of drug resistance of HIV1 was at lower level in Fujian,but with the increasing of case therapy number and extension of therapy duration,the drug resistance surveillance of HIV cases should still be strengthen in the future.