Abstract:Objective To compare the liver toxicity and reproductive endocrine effects of exposure after female rats exposed to triclosan during the weaning to sexual Abstract: ObjectiveTo compare the hepatotoxicity and reproductive toxicity in the female rats exposed to triclosan during weaning to sexual maturity. MethodsFemale Wistar rats were injected subcutaneously with 0,30,90 and 270 mg/kg triclosan from postnatal 23 days to 76 days.The body weight was recorded,the main organ (liver,ovary and uterine etc) coefficients were calculated and the biochemical indicators of blood serum were detected.Histopathological changes of liver,ovary and uterine were observed by using HE staining method.The thickness of the endometrium of uterine were measured.The levels of glutathione peroxidase,superoxide dismutase and malondialdehyde of the liver were detected.The levels of estradiol and progesterone in serum were detected by using ELISA method. ResultsThe organ coefficient of uterine,the thickness of uterine epithelium and endometrium and estradiol concentration for the serum in 90 and 270 mg/kg groups were higher than those in control group.The endometrial glands in 270 mg/kg group were more than those in control group.The progesterone levels in 30,90 and 270 mg/kg group were higher than those of control group respectively.Conclusion Under the conditions of this study,triclosan exposure during the weaning to sexual maturity will result in the disorders of reproductive endocrine for female rats,whereas no liver toxicity was obviously observed.