Abstract：Objective To investigate the epidemiological characteristics of chronic hepatitis B (HBV) in different immunization intervention cohorts for screening and prevention of the disease in Fujian. Methods According to HBV immunization strategy, the target populations were divided into different intervention cohorts by using cohort study. The results of the incidence and death of chronic HBV in the populations were observed from 2004 to 2020, and epidemiological characteristics of chronic HBV in the populations were analyzed. Results There were 696 934 cases of chronic HBV and 195 death cases in different immunization populations in Fujian from 2004 to 2020. The annual incidence were 110.08/105 and mortality 0.031/105. The total trend was consistent with the polynomial equation (R2 =0.678). The number of cases in control group was 92.2%, personyear morbidity 139.78/105, and the mortality 0.041/105. The morbidity of intervention group (31.45/105) was lower than that of control group (χ2 =134 443.79, P＜0.01), the EI value was 4.44. The mortality rate of intervention group was also lower than that of control group (χ2 =53.25, P＜0.01), the EI value was 8.83. EI values of intervention group A which were higher than the mean level (21.15) were followed by Nanping (40.13),Sanming (35.10), Longyan (33.33), Zhangzhou (23.15) and Quanzhou (21.74). Conclusion There are large number of chronic HBV cases in Fujian, routine immunization for newborn babies should be carried out, and HBV vaccination for adult，actively screening and treatment for chronic HBV cases should be the focus on in the future.
2021, Vol. 27 
