Investigation and analysis on seroepidemiology of hepatitis B in Fujian,China,2019-2020
YANG Xiuhui1,ZHOU Yong1,ZHANG Hairong1,ZHANG Suhan1,HUANG Lifang1,LIN Haibing2,YOU Na3
1.Fujian Center for Disease Control and Prevention (Fujian Provincial Key
Laboratory of Zoonosis Reserch),Fuzhou Fujian 350001,China;
2.Public Health School of Xiamen University,Xiamen Fujian 356100,China;
3.Public Health School of Fujian Medical University,Fuzhou Fujian 350001,China
Abstract:Objective To investigate the epidemiological characteristics of hepatitis B virus (HBV) infection, and evaluate the control and prevention effects for further formulating the prevention strategies in Fujian. Methods Target population were selected and investigated by using probability proportion to size and stratified random sampling method. The serological indexes of HBV infection were detected by enzymelinked immunosorbent assay. Results Totally 8 398 population were investigated during 2019 and 2020.and the positive rates of HBsAg,HBsAb,HBeAg,HBeAb and HBcAb were 6.2%,61.5%,0.9%,11.3% and 30.7% respectively. The positive rates of HBsAg aged <15,15~29 and 30~69 were 0.5%,3.7% and 12.9% respectively,the positive rates were increasing with age. HBsAg positive rate of HBsAgpositive mothers’children(2.5%) was higher than that of mother with HBsAg negative (0.1%,Fisher P=0.032). The coverage of HBV vaccine increased from 19.0% in the birth cohort before 1992,to 99.3% in 2012-2020,and HBsAg positive rates decreased from 12.8% to 0.2%.Compared with the results in 1992 and 2006,the HBsAg positive rates aged 1-59 in 2019-2020 were decreased by 11.6 and 5.06 percentage point. Conclusion With vaccination as the main strategy,the control and prevention measures of hepatitis B in Fujian show great achievements,the infection rates of HBV reach to a new lowest level. The control and prevention for population with ≥ 30 years old and mothertochild blocking for HBsAg positive mothers will still be key emphasis in work and a difficult point in the future.